摘要
目的探讨人血清脂联素水平与冠状动脉粥样硬化程度的关系。方法根据冠状动脉造影结果和临床表现,将162例疑诊冠心病患者进行分组,用放射免疫法检测血清脂联素水平,同时测定患者血压、血脂、血糖等相关指标。结果确诊冠心病患者血清脂联素水平(17.21±10.67 mg.L-1)明显低于阴性对照组(32.94±15.18 mg.L-1,P<0.01),脂联素水平随着动脉粥样硬化程度的加重呈进行性下降。血清脂联素水平与冠状动脉的狭窄程度、总胆固醇、甘油三酯、低密度脂蛋白胆固醇成负相关(P<0.01),与高密度脂蛋白胆固醇呈正相关(P<0.05)。结论血清脂联素水平随动脉粥样硬化的发展呈进行性下降,有助于临床评价冠心病病变程度及其进展。
AIM To explore the relationship between the level of serum adiponectin and the severity of coronary artery athemsclerosis. METHODS According to coronary angiography and clinical manifestration, 162 cases with suspected coronary heart disease were divided into groups. Fasting serum adiponeetin was assayed by radioimmunoassay, and related parameters such as blood pressure,fasting blood glucose,lipids were measured. RESULTS The serum level of adiponeetin in patients with definited coronary heart disease （17.21 ± 10.67 mg·L^-1）was decreased as compared with that in the negative controls （32.94 ± 15.18 mg·L^-1, p 〈 0.01 ）. The level of adiponeetin fell in parallel with the severity of coronary artery atherosclerosis in these patients. Serum adiponeetin level was negatively correlated with the extent of coronary artery stenosis, the level of total cholesterol, triglyceride, lower density lipoprotein cholesterol （ P 〈 0.01 ）, while positively correlated with high density lipoprotein cholesterol （P 〈 0.05）. CONCLUSION The level of serum adiponeetin decrease progressively with the advancing coronary atheroselerosis, which may predicts the oecurrence and development of coronary heart disease.
出处
《江苏药学与临床研究》
2006年第5期323-325,共3页
Jiangsu Pharmacertical and Clinical Research
