血管紧张素转换酶抑制剂抑制大鼠损伤动脉内膜肥厚的机制

Mechanism of angiotensin-converting enzyme inhibitor in inhibiting intimal hypertrophy of injured rat artery

目的:研究血管紧张素转换酶抑制剂(ACEI)抑制大鼠颈总动脉损伤后内膜肥厚的机制。方法:Wistar大鼠20只,制备颈总动脉球囊导管损伤模型,实验组给予ACEI,对照组仅给予溶剂。测定2和5 d动脉中膜血小板衍生生长因子B(PDGF-B)和弹性蛋白酶ⅢB阳性细胞率。结果:ACEI显著降低大鼠损伤动脉中膜PDGF-B和弹性蛋白酶ⅢB阳性细胞率(P<0.01)。结论:ACEI通过抑制PDGF和弹性蛋白酶减轻内膜肥厚。

Objective： To study the mechanism of angiotensin-converting enzyme inhibitor （ ACEI ） in inhibiting the intimal hypertrophy of injured rat artery. Methods： The rat model of injured carotid artery was established by balloon catheter. Twenty Wistar male rats were divided into ACEI group and control group. The percentage of ceils positive for platelet-derived growth factor-B （PDGF-B） and elastase Ⅲ B was determined 2 and 5 days after the injury. Results： The percentage of ceils positive for PDGF-B and elastase Ⅲ B in ACEI group was significantly higher than that in control group. Conclusion： ACEI alleviates intimal hypertrophy by inhibiting PDGF and elastase.