帕夫林胶囊治疗干燥综合征的临床观察

Clinical application of total glucosides of paeony in Sjogren syndrome

目的:评价帕夫林胶囊(白芍总甙)治疗干燥综合征(SS)的有效性及安全性,探讨帕夫林胶囊对其他风湿性疾病的疗效及安全性。方法:选择SS病人56例,给予帕夫林胶囊600 mg,日3次口服,连续观察9个月(36周),于服药前、服药后12,24,36周检测血沉、免疫球蛋白、唾液流量、Schirmer试验、血清蛋白电泳及应用10 cm目视模拟标尺法分别测定医生和病人对病情程度的评估。结果:治疗12周时有效率为21.4%(12/56),显效率为5.0%(3/56),治疗24周时有效率为55.3(%31/56),显效率为14.3%(8/56),治疗36周时有效率为57.1(%33/56),显效率为21.4%(12/56)。治疗12周内轻度不良反应发生率为14.3(%8/56)。结论:帕夫林胶囊治疗SS是有效和安全的,可以长期应用。

Objective： To investigate the efficacy and safety of total glucosides of paeony （TGP） in treating Sjoegren syndrome （SS） and thus find an effective method for treating and other rheumatic diseases. Methods： Fifty-six patients with SS were selected and treated with TGP （600 mg, 3 times daily） for 36 weeks. The erythrocyte sedation rate （ESR）, immunoglobulin, and salivary flow were determined. Schirmer test,serum protein electrophoresis,and 10 cm visual analogue scale （VAS） were performed before and every 12 weeks after the administration of TGP to evaluate the degree of the disease for both physicians and patients. Results： The effective rate and markedly effective rote of TGP were 21.4% （ 12 of 56 patients） and 5.0% （3 of 56 patients） 12 weeks after the treatment, 55.3% （31 of 56 patients） and 14.3% （8 of 56 patients） 24 weeks after the treatment, and 57.1% （33 of 56 patients） and 21.4% （12 of 56 patients） 36 weeks after the treatment. The incidence of mild side effect within 12 weeks of the treatment was 14.3% （8 of 56 patients）. Conclusion： TGP is effective and safe in the treatment of SS, so it can be administrated for a long period of time.