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KRAB型锌指蛋白(KZNF)的研究进展 被引量：5

Progress in the Study of KRAB Zinc Finger Protein
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摘要 KRAB型锌指蛋白是哺乳动物中最大的转录调控因子家族,它的多数成员在基因组上成簇分布。其结构特征是N端含有KRAB结构域,C端含有多个C2H2型锌指结构。KRAB结构域为一蛋白质-蛋白质相互作用区,可以与多种协同转录抑制因子和转录因子结合,使KRAB型锌指蛋白作为转录因子和／或转录调控因子发挥依赖于DNA结合的转录抑制功能,在胚胎发育、细胞分化、细胞转化及细胞周期的调控中发挥重要功能。 The zinc finger proteins containing the Kruppel-associated box domain （KRAB） constitute the largest single family of transcriptional regulators in mammals. Many genes encoding members of this family are arranged in clusters. KRAB-containing proteins are characterized by the presence of 4 and over 30 C2H2 zinc-finger motifs and a KRAB domain near the amino terminus of the protein. KRAB domain behaving as a protein-protein interaction domain could bind to corepressor proteins and/or transcription factors, and that the KRAB-containing proteins could act as a repressor or corepressor and play a key role in transcriptional repression. Members of the family are involved in embryonic development, cell differentiation, cell proliferation, apoptosis, neoplastic transformation and cell cycle regulation.
作者 田春艳 张令强 贺福初
机构地区 军事医学科学院放射与辐射医学研究所系统生物学研究室
出处 《遗传》 CAS CSCD 北大核心 2006年第11期1451-1456,共6页 Hereditas（Beijing)
基金 国家高技术研究发展计划项目(863计划)(编号:2004AA221100 2005AA220060 2002BA71A02-5) 国家自然科学基金(编号:30321003 30600310)资助~~
关键词 KRAB KZNF C2H2型锌指 KAP-1 转录抑制 KRAB KZNF C2H2 zinc finger KAP-1 transcriptional repression
分类号 Q75 [生物学—分子生物学]
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参考文献34

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二级参考文献8

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共引文献1

同被引文献36

  • 1杨冬,姜颖,贺福初.KAP-1:转录调控中的一个桥梁分子[J].遗传,2007,29(2):131-136. 被引量：9
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  • 5Verona RI,Mann MR,Bartolomei MS.Genomic imprint-ing:intricacies of epigenetic regulation in clusters.Annu Rev Cell Dev Biol,2003,19:237-259.
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  • 7Li X,Ito M,Zhou F,Youngson N,Zuo X,Leder P,Fergu-son-Smith AC.A maternal-zygotic effect gene,Zfp57,maintains both maternal and paternal imprints.Dev Cell,2008,15(4):547-557.
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引证文献5

二级引证文献16

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2006年 第11期

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