摘要
目的研究潜溶剂和环糊精对难溶性药物的联合增溶作用。方法采用相溶解度法研究药物在不同混合溶剂中的相溶解度,利用已建立的数学模型对这种联合增溶作用作出评价和解释,非线性回归分析估计模型参数。结果两个难溶性药物的增溶模型判定系数R2分别为0.993和0.992,拟合效果很好,溶解度的实测值和模型预测值一致。结论该数学模型可以用于解释和预测潜溶剂和环糊精对难溶性药物的联合增溶作用。
Aim To investigate the combined effect of cosolvent and cyclodextrin （CD） on solubilization of insoluble drugs. Methods Phase-solubility method was applied to determine solubilization of two diterpenoids in cosolvent / cyclodextrin combinations. The combined effect was evaluated and explained with an established mathematical model, and the model parameters were calculated by means of nonlinear regression analysis. Results The strong agreement between the predicted and the observed solubility data supports the validity of the proposed model, with the determination coefficients of two regression models were 0. 993 and 0. 992, separately. Conclusion The validated mathematical model can be used to explain and predict the combined solubilization of the two insoluble drugs in different cosolvent systems.
出处
《药学学报》
CAS
CSCD
北大核心
2006年第10期950-955,共6页
Acta Pharmaceutica Sinica
关键词
潜溶剂
环糊精
难溶性药物
增溶
数学模型
cosolvent
cyclodextrin
insoluble drug
solubilization
mathematical model
