摘要
目的:探讨鼻咽癌组织中PCNA、PTEN的表达水平与预后的关系。方法:采用免疫组织化学S-P法测定56例鼻咽癌组织中PCNA、PTEN的表达,分析其与原发灶范围、放疗后局部肿瘤残留、颈淋巴结有无转移及生存期的关系。结果:PCNA、PTEN的表达与原发灶范围、放疗后肿瘤残留无关(P>0·05),与颈淋巴结转移有关(P<0·05)。单因素分析PC-NA、PTEN蛋白表达与鼻咽癌的生存亦无相关性(P>0·05)。结论:PCNA和PTEN的免疫组化检测对鼻咽癌的预后无重要的预测价值。
Objective:To evaluate the expression of PCNA and FFEN in nasopharyngeal carcinoma(NPC) and the correlation to prognosis. Methods:The expression of PCNA and PTEN were detected by the S-P immunohistochemical method in 56 NPC patients, and analyzed the relationship of their expressions with extent of primary lesion, lymph node metastasis, residual after radiotherapy and surival. Results:There were no correlation of PCNA and PTEN staining with extent of primary lesion and residual after radiotherapy( P 〉 0. 05), but PTEN was correlation with lymph node metastasis( P 〈 0. 05). The result of univariate analysis showed that the expression of PCNA and PTEN were no significant differences in surival( P〉0.05 ). Conclusion: Immunostaining of PCNA and PTEN has no important value for prognosis in nasopharyngeal carcinoma.
出处
《临床肿瘤学杂志》
CAS
2006年第10期755-757,共3页
Chinese Clinical Oncology
基金
广西壮族自治区卫生厅重点基金资助(重200019)
关键词
鼻咽癌
PCNA
PTEN
免疫组化
Nasopharyngeal carcinoma
PCNA
PTEN
Immunohistochemical method