先兆早产孕妇的牙周状况分析

Analysis of periodontal status in pregnant women with a diagnosis of threatened premature labor

目的:通过比较先兆早产(TPL)孕妇与正常孕妇的牙周状况,探讨先兆早产孕妇的牙周状况、血清IL-6水平及与早产的关系。方法:收集诊断为TPL住院治疗的孕妇40例,同期定期产前检查但无产兆的正常孕妇40例作为对照组。检查记录菌斑指数(PLI)、探诊深度(PD)、临床附着丧失(CAL)和出血指数(BI),计算牙周炎位点(PD>3mm,CAL≥2mm)率。ELISA法检测血清IL-6水平。采用SPSS11.0统计软件包对相应数据进行χ2检验、t检验和Pearson相关分析。结果:TPL孕妇中26例足月产(TPL-TB),14例早产(TPL-PB);对照组(Non-TPL)40例均足月产。TPL-TB和TPL-PB组间的分娩孕周和新生儿出生体重有显著差异(P<0.05)。TPL组的PLI、牙周炎位点率和血清IL-6水平显著高于对照组。先兆早产组中,TPL-PB组的PLI、BI、牙周炎位点率显著高于TPL-TB组。分娩孕周和牙周炎位点率、BI呈显著负相关(P<0.05)。结论:先兆早产孕妇的牙周状况显著差于正常孕妇,血清IL-6水平显著高于正常孕妇,牙周感染是否为早产的原因之一,有待于进一步明确。

PURPOSE： To evaluate the associations between periodontal conditions and delivery outcomes in pregnant women with a diagnosis of threatened premature labor （TPL）. METHODS： Eighty systemically healthy pregnant women were enrolled in the study. The case group was composed of 40 pregnant women hospitalized with the diagnosis of TPL and the control group was composed of 40 normal pregnant women. Periodontal examinations included assessments of plaque index （PLI）, clinical attachment loss （CAL）, probing depth （PD）, bleeding index （BI） and the percentage of periodontitis sites （PD〉3 mm, CAL≥ 2mm ）. The serum level of IL-6 was determined using commercially available enzyme-linked immunoassays（ELISA）. The data were analyzed with SPSS11.0 software package for X^2 test. Student＇s t test and Pearson correlation analysis. RESULTS： 40 subjects were clarified as TPL and 14 as TPL-PB. 26 TPL women subsequently delivered TB infants. No infants were delivered as PB in 40 subjects clarified as non-TPL. There were no significant differences in the mean ages and gestational age at examination between the non-TPL and TPL groups or between the TPL-TB, and TPL-PB groups. There were significant differences in gestational age at delivery and birth weight between the non-TPL and TPL groups or between the TPL-TB, and TPL-PB groups （P〈0.05）. The mean PLI. percentage of periodontitis sites and IL-6 levels were significantly higher in the TPL group than those of the non-TPL group. The mean PLI, BI, and percentage of periodontitis sites were significantly higher in the TPL-PB group than those of the TPL-TB group. Significant negative correlations were observed between the gestational age at delivery and percentage of periodontitis sites as well as BI （P〈0.05）. CONCLUSION： Periodontal inflammation might be involved in the pathogenesis of preterm birth.