依达拉奉对重症脑梗死脑脊液TNF-α、IL-6的影响

Effect of Edaravone on Cerebrospinal Fluid TNF-α/IL-6 in Acute Serious Cerebral Infarction

目的:观察依达拉奉(Edaravone,商品名必存)对重症脑梗死患者脑脊液中TNF-α、IL-6的影响,探讨必存对脑梗死的脑保护机制。方法:选择72小时内的重症脑梗死病人66例,随机分为对照组31例和治疗组35例,对照组采用常规治疗,治疗组加用必存15mg/d治疗10天,在治疗前后腰穿取脑脊液,用ELESA法检测脑脊液中TNF-α、IL-6,并在3周后进行神经功能缺损评分。结果:治疗后必存组TNF-α和IL-6的水平下降与对照组比较,具有显著统计学意义(P<0·01),治疗组对脑梗死的有效率高于对照组,具有统计学意义(χ0·052=3·96,P<0·05)。结论:必存能够通过清除自由基减轻梗死后炎症的发生,对脑梗死有脑保护作用。

Objective： To study the effect of edaravone cerebrospinal fluid TNF - α and IL- 6 with edaravone with acute serious cerebral infarction, and eveluate its protective mechanism. Methods. 66 cases of cerebral hemorrhage in 72h were randomly divided into treatment group （35 cases） and control group （31 cases）, TNF- α/IL. 6 in cerebrospinal fluid were detcted by ELESA at pretherapy and after given treatment 10days. Neurological functional deficit scores were utilized for assessment before given treatment, On the 21th day after treatment, the patient was assessed again, and the efficacy was recorded. Results： After 10 days treatment, the level of TNF - α. IL - 6 more transparently fall in treatment than that of control group, there were significant difference between the two groups （ P 〈 0.01 ） ; On the 21th day after treatment, there were also significant differences between the two groups in terms of apparent effect rate （treated group： 60% ; control group. 35% ; χ0.05^2 = 3.96, P 〈 0.05）. Conclusion： Edaravone alleviate inflammation via cleaning free radical, so it mayprotect brain tissue and accelerate the recovery of neural function after serious cerebral infarction.