PEDF与视网膜新生血管

PEDF and Neovascularization Disease

近年来糖尿病性视网膜病变、视网膜静脉阻塞、Eales病、早产儿视网膜病变、年龄相关性黄斑变性的发病率越来越高,已经成为致盲的主要眼病。新生血管形成是这些眼病共有的病理性改变,并且是其致盲的主要原因。研究发现新生血管形成因子与抑制因子之间的平衡失调是新生血管形成的重要机制,抑制血管增生已经成为治疗这类疾病的新靶点。色素上皮细胞衍生因子(pigmentepitheli-umderivedfactor,PEDF)是目前最有效的血管增生抑制剂之一。本文将对PEDF的概况,PEDF与视网膜新生血管的关系,PEDF在视网膜新生血管性疾病中的用途等方面进行综述。

the incidence of these diseases is increasing such as diabates retinopathy （DR）, retinal vein obstruction （RVO）, the Eales sickness, premature retinopathy, and age-related macular degeneration. These diseases already have become the main causes of blindness. The neovascularization is their mutual pathological change, and is the main reason of blindness. Researches show that the disorder of the balance between the promotion factor and the inhibition factor of neovascularization is an important mechanism of the neovascularization. Suppressing the new blood vessel proliferation have already become the new target spot to treat this kind of disease. At present, the pigment epithelium derived factor （PEDF） is one of the most effective blood vessel proliferation inhibitors. This article will carry on the summary to the PEDF survey, the relation between PEDF and the retina newborn blood vessels, the function of PEDF to treat the retinal new vascular diseases, and so on.