p63和TTF-1在肺癌组织中的表达及鉴别诊断意义

Expression and differential diagnostic significance of p63 and TTF-1 in lung cancer tissues

目的:探讨p63和TTF-1蛋白在肺癌不同组织类型中的表达特点及鉴别诊断的价值。方法:应用免疫组织化学S-P法检测116例原发性肺癌组织中p63和TTF-1蛋白的表达情况。结果:p63在肺鳞癌中阳性表达率为100%(47/47),而在其他组织类型肺癌中基本不表达。TTF-1在肺小细胞癌和肺腺癌中阳性表达率分别为93.3%(14/15)和93.5%(43/46),而在鳞癌中未见表达。结论:p63可作为肺鳞状上皮源性肿瘤标记物,是判断鳞癌的可靠指标。TTF-1可作为肺小细胞癌、腺癌的特异性标记。联合检测p63和TTF-1对肺癌不同组织类型的诊断、鉴别诊断具有较高的实用价值,尤其可作为鉴别分化差的鳞癌、腺癌和小细胞癌的指标。

Objective ： To investigate p63 , rVFF - 1 expression and the value of the differential diagnoses in different tissue types of lung cancer . Methods ： Using S - P immunohistochemical methods, we examined the expression of p63 and TTF- 1 in 116 cases of primary lung cancer. Results： The positive rate of p63 was 100% （47/47） in primary lung squamous cell carcinoma . In contrast, other histologic types of lung cancer were negative or low expression. The positive rates of TTF - 1 expression were 93.3% （ 14/15 ） and 93.5% （43/46） respectively in small cell carcinomas and adenocarcinomas of lung. In contrast, lung squamous cell carcinoma was negative. Condusion： p63 and TTF - 1 may be a useful immunohistochemical marker for lung squamous cell carcinoma and small cell carcinoma, adenocarcinoma of lung respectively . Combined examination of p63 and TTF - 1 is valuable in the differential diagnosis in different histologic types of lung cancer. Especially it may be as a marker in distinguishing poorly differen- tiated squamous carcinoma, small cell carcinoma and adenocarcinoma of lung .