CD105标记的MVD在乳腺癌中的表达及其临床意义

Expression and significance of MVD marked by CD105 in the tissue of breast carcinoma

目的：检测乳腺癌组织中CD105表达，探讨其与相关生物学因子及预后的关系。方法：采用免疫组化方法（sP）检测乳腺癌组织中CD105、IL-8、VEGF、ER、PR表达水平。结果：①以CD105标记的微血管密度值（MVD）在乳腺癌组织中计数值范围为0—17．67，中位数为5．33；②MVD与VEGF及IL-8表达均呈现一定正相关性，rs值分别为0．361、0．359，P=0．000；③MVD与临床分期、淋巴结转移状况、组织学分级相关（P〈0．05）；④MVD与乳腺癌预后有关（P=0．004）；⑤MVD与ER、PR、肿瘤大小及病理类型无关（P〉0．05）。结论：CD105标记MVD与影响乳腺癌患者预后的某些生物学因子及临床指标相关，MVD高表达，预后差，可作为判断乳腺癌预后指标。

Objective：To study the expression of CD105 in breast cancer and to explore the correlation between the expression of CD105 and biological factors and prognosis of breast cancer. Methods： Immunohistochemistry was used to measure the expression of CD105, IL- 8, VEGF, ER and PR in breast carcinoma. Results： ①The count of the microvessel density （MVD） which was marked by CD105 in breast cancer tissues was 0 - 17.67, the median was 5.33.②The expression of MVD was correlated positively with the VEGF and IL - 8, rs = 0.361 , 0. 359, both P = 0.000. ③The expression of MVD was associated with the axillary lymph node metastasis, the different histological grade, the clinical stage （ P 〈 0.05 ）.④The expression of MVD was associated with prognosis of breast cancer, P = 0. 004. ⑤The expression of MVD was not related to ER, PR, the tumor diameter and the pathology type （ P 〉0.05）. Conclusion： The expression of MVD marked by CD105 in breast carcinoma has closed relationship with prognsotic factors, and can be used as an index for predicting the prognosis.