得力生诱导直肠癌细胞凋亡的临床观察

Clinical study of the differentiation effects on rectal cancer exerted by the compound injection DeLiSheng(DLS) of Chinese medicine

目的:观察复方中药针剂得力生对直肠癌细胞凋亡的诱导分化作用。方法:经病理诊断为直肠癌的患者50例,随机分为两组。治疗组24例术前应用得力生静脉滴注及生理盐水稀释保留灌肠,对照组26例仅应用等量生理盐水灌肠。用药后两组均行手术切除肿瘤,术中取新鲜标本送电镜检查。结果:治疗组有17例便血、肛门坠胀感减轻,7例不全性肠梗阻患者腹痛减轻,术后电镜观察标本可发现凋亡的癌细胞;对照组无上述改变。结论:复方中药得力生可诱导直肠癌细胞凋亡,术前尽早应用可提高疗效。

Objective：To observe the differentiation effects on rectal cancer exerted by the compound injection Delisheng（DLS） of Chinese medicine. Methods： Randomly divided the 50 patients diagnozed with pathological rectal cancer into two groups. Before the operation the treated group （24 patients） under went DIS intravenous drip and the clysis with diluted physiological saline, whereas the control group （26 patients） were only clystered with physiological saline of the same quantity as the former. Then patients in both groups received operations to excise tumors. The fresh specimens taken in the operations were examined under the electrical microscope. Results： Senvevteen patients of the treated group hematochezia, alleviation of bulge in anus as well, and among this group 7 patients once diagnozed with incomplete intestinal obstruction also encounter the alleviation. After the operation some withered and dead cancer cells were found under the electrical microscope. However, the control group had no similar changes as mentioned above. Conclusion： Compound Chinese medicine DLS can lead the rectal cancer cells to dead and withered conditions, therefore compound Chinese medicine DES should be applied as early as possible before the operatinn so that the curative effects will be improved.