期刊文献+

得力生诱导直肠癌细胞凋亡的临床观察 被引量:5

Clinical study of the differentiation effects on rectal cancer exerted by the compound injection DeLiSheng(DLS) of Chinese medicine
下载PDF
导出
摘要 目的:观察复方中药针剂得力生对直肠癌细胞凋亡的诱导分化作用。方法:经病理诊断为直肠癌的患者50例,随机分为两组。治疗组24例术前应用得力生静脉滴注及生理盐水稀释保留灌肠,对照组26例仅应用等量生理盐水灌肠。用药后两组均行手术切除肿瘤,术中取新鲜标本送电镜检查。结果:治疗组有17例便血、肛门坠胀感减轻,7例不全性肠梗阻患者腹痛减轻,术后电镜观察标本可发现凋亡的癌细胞;对照组无上述改变。结论:复方中药得力生可诱导直肠癌细胞凋亡,术前尽早应用可提高疗效。 Objective:To observe the differentiation effects on rectal cancer exerted by the compound injection Delisheng(DLS) of Chinese medicine. Methods: Randomly divided the 50 patients diagnozed with pathological rectal cancer into two groups. Before the operation the treated group (24 patients) under went DIS intravenous drip and the clysis with diluted physiological saline, whereas the control group (26 patients) were only clystered with physiological saline of the same quantity as the former. Then patients in both groups received operations to excise tumors. The fresh specimens taken in the operations were examined under the electrical microscope. Results: Senvevteen patients of the treated group hematochezia, alleviation of bulge in anus as well, and among this group 7 patients once diagnozed with incomplete intestinal obstruction also encounter the alleviation. After the operation some withered and dead cancer cells were found under the electrical microscope. However, the control group had no similar changes as mentioned above. Conclusion: Compound Chinese medicine DLS can lead the rectal cancer cells to dead and withered conditions, therefore compound Chinese medicine DES should be applied as early as possible before the operatinn so that the curative effects will be improved.
出处 《现代肿瘤医学》 CAS 2006年第11期1413-1415,共3页 Journal of Modern Oncology
基金 福建省科技厅重点项目(编号:2005Y028)
关键词 复方中药针剂 得力生 直肠癌 诱导分化 compound infection of Chinese medicine Delisheng rectal cancer differentiation
  • 相关文献

参考文献7

二级参考文献57

  • 1陈培丰,刘鲁明.中药蛇六谷抗癌活性及诱导癌细胞凋亡[J].中国中医基础医学杂志,2000,6(9):30-33. 被引量:30
  • 2孙世明.蟾酥的现代临床应用进展[J].四川中医,1996,14(12):12-13. 被引量:8
  • 3迟永春,万方,王石麟,潘子昂,盛瑞红.硒甲祛邪方的抗癌机理与诱导细胞凋亡[J].中日友好医院学报,1996,10(4):283-286. 被引量:8
  • 4余桂清 梁富义.中西医结合防治肿瘤研究进展.中西医结合防治肿瘤[M].北京:中国协和医科大学联合出版社,1995.5-22.
  • 5Steven WH etts.To dieornottodie:anoverview of Apoptisis and it srole in disease[J].JAMA,1998,28:2793
  • 6Yano H,Mizoguchi A,Fukuda K.The herbal medicine sho-saiko-to inhibits proliferation of cancer[J].Cancer Res,1994,54(2):448-54
  • 7End DW.Look RA,Shaffer NL.Non-selective inhibition of mammalian protein kinases by flavinoids in vitro[J].Res Commun Chem Pathol Pharmacol,1987,56(1):75
  • 8Chen GQ,Xhu J,Shi XG.In vireo studies on cellular and molecular mechanisms of arsenic[J].Blood,1996,88(3):1052
  • 9Masuda Y,Kawazoe N,Nakajo S.Bufalin induces apoptosis and influences the expression of apoptosis-related genes in human leukemia cells[J].Leuk Res,1995,19(8):549
  • 10王绪辉 黄晖.抗风湿消肿散结剂对人类肿瘤细胞的抑制和凋亡作用[J].中国中西医结合风湿病杂志,1998,7(2):84-85.

共引文献107

同被引文献121

引证文献5

二级引证文献24

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部