摘要
采用双抗体夹心法ＥＬＩＳＡ检测了２０例前列腺癌、２０例前列腺增生（ＢＰＨ）患者前列腺组织提取物的免疫反应性转化性生长因子β１（ＴＧＦ－β１）的含量。ＴＧＦ－β１在两组的含量分别为２４１６±７９０．６ｎｇ／ｇ组织和１９３４．２±６７３．０ｎｇ／ｇ组织，二者的差异具有显著性意义。４例正常前列腺的ＴＧＦ－β１含量为４５９．３±１８７．１８ｎｇ／ｇ组织，比两个实验组低得多，提示ＴＧＦ－β１不仅参与前列腺的生理过程，而且可能对上述两种疾病的发生和发展具有重要的生物学作用。
Abstract Prostate tissu extracts from 20 patients with prostatic carcinoma (PC) and 20patients with benign prostatic hyperplasia (BPH) were quantitatively assayed for expression of immunoreactive transforming growth factor-β1, (TGF-β1 ) with sand-wich ELISA. The content of TGF-β1, was significantly higher in PC (2416±790. 6ng/g tissue) than that in BPH (1934. 2±673.0ng/g tissue). While the content of TGF-β1 in 4 normal prostates (459. 3 ± 187. 18ng/g tissue) was much lower than that in both experimental groups. The findings suggest that TGF-β1 may be biologically important not only in the physiological process of prostate but also in the development of PC and BPH.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1996年第3期154-156,共3页
Cancer Research on Prevention and Treatment
