血管内皮生长因子和转化生长因子β_1在儿童过敏性紫癜中的作用探讨

Effects of serum vascular endothelial growth factor and transforming growth factor-beta 1 on children with henoch-schoenlein purpura

目的探讨过敏性紫癜(HSP)患儿血清血管内皮生长因子(VEGF)和转化生长因子β1(TGFβ1)水平的变化及其在HSP发病中的作用。方法采用双抗体夹心ELISA方法检测20例急性期HSP患儿及15例正常儿童血清VEGF和TGFβ1水平。结果急性期HSP患儿血清VEGF和TGFβ1水平(533.85±127.63)ng/L,(84.25±19.32)ng/m l明显高于正常对照组(68.93±19.16)ng/L,(65.95±17.38)ng/m l,差异有显著性意义(P<0.01)。结论VEGF和TGFβ1可能参与了HSP的发病过程,可能是介导HSP血管炎症损伤过程中的重要细胞因子,为进一步认识HSP发病机制提供了实验依据。

Objective To investigate the changes of serum vascular endothelial growth factor （ VEGF） and transforming growth factor-beta 1（TGF-β1） and their effects on pathogenesis in children with Henoch-Schoenlein purpura. （HSP）. MethodsSerum VEGF and TGF-β1 were detected by sandwich ELISA in 20 children with HSP in acute phase and 15 normal children. Results The serum VEGF and TGF-β1 levels in children with HSP in acute phase were （533.85 ± 127.63） ng/L and （84.25 ± 19.32） ng/ml, which were significantly higher than normal controls（68.93 ± 19.16） ng/L and （65.95 ± 17.38） ng/ml （ P 〈 0. 01 ）. Conclusion The serum VEGF and TGF-β1 levels increase markedly in acute phase of HSP, which shows that VEGF and TGF-β1 may play an important role in pathogenesis of HSP. It is of great value in understanding the pathogenesis of HSP in children.