汉防己甲素对矽肺大鼠胶原代谢的作用

Effect of tetrandrine on collagen metabolism in silicosis rats

从胶原蛋白质水平和ｍＲＮＡ水平分析了汉防己甲素（汉甲）的抗纤维化作用。大鼠染石英尘后肺组织的全肺干重、全肺胶原含量以及血清中Ⅰ型胶原含量均上升，汉甲可以抑制以上各种指标的上升趋势。ｃＤＮＡ－ｍＲＮＡ原位杂交实验从转录水平上进一步证明，汉甲对胶原代谢的影响发生在胶原合成的起始阶段。

The authors studied the anti silicosis effect of tetrandrine (TT) by measuring both collagen protein level and collagen mRNA level. After the rats were dusted, the dry weight of the lungs, the collagen contents of whole lungs and the serum collagen levels increased. TT treatment inhibited these changes. cDNA mRNA in site hybridization observation revealed that TT has an effect on collagen expression. These results provide guidance to the drug selection in the silicosis.