醒脑健神胶囊对实验性脑出血大鼠脑内脑啡肽（ENK）影响的实验研究

Effects of Xing Nao Jian Seen Capsule on Enkephalin(ENK)in the Brain of Rats with Cerebral Hemorrhage

用免疫组织化学ＡＢＣ方法观察中药醒脑健神胶囊对实验性脑出血大鼠脑内脑啡肽（ＥＮＫ）的影响。结果发现，脑出血后１天、３天和７天脑内ＥＮＫ样阳性纤维及终末的密度高于正常对照组，治疗组ＥＮＫ样阳性纤维及终末的密度在脑出血后第亚天和第７天比脑出血组低，但在第３天比脑出血组高。根据前人的研究和本实验结果，我们推测ＥＮＫ可能参与了脑出血的病理生理过程。醒脑健神胶囊可调节脑内ＥＮＫ的含量，减轻脑组织的损伤，使脑出血后某些神经症状得以改善。

Immunohistochemical ABC method was used to show the changes of ENK immunoreactivity in the brain of rats with cerebral hemorrhage. Collagenase was injected into the right caudatus-putamen nucleus of rats to induce intracerebral hemorrhage. It was found that the amount of ENK like-immunoreactive nerve fibers in model rats was higher than that of normal rats on the 1st day, 3rd day and 7th day. ENK amount in group treated with Xing Nao Jian Shen capsule was less than that of model (hemorrhage) group on the 1st day, 7th day, but was higher than that of model group on 3rd day. The results indicated that ENK might play some pathophysiological roles in the cerebral homorrhage. Xing Nao Jian Shen capsule could regulate the contents of ENK in the cerebrum,reduce brain injury and improve neurological function following cerebral hemorrhage.