串珠镰刀菌素是克山病致病因素吗？

Is moniliformin (MF) an etiologic factor of Keshan disease (KD)? Conclusion from the study on the relation of MF to KD

拟通过对串珠镰刀菌素（ＭＦ）毒性和影响因素研究，以及ＭＦ对克山病区和非病区粮食侵染程度的调查来论证串珠镰刀菌素是否有可能是克山病的致病因素。研究结果表明：ＭＦ致毒靶器官是心脏和睾丸；致毒作用点以ＰＤＨ，ＳＤＨ，ＧＰＸ和ＰＨＧＰＸ等酶为主；在ＭＦ致毒心肌中未见类似克山病的病理和酶谱改变；ＭＦ毒性与染毒对象的硒营养状态无关，补硒或ＶＥ对ＭＦ毒性没有抑制或减轻作用，与硒可预防克山病的事实不符；串珠镰刀菌在克山病区和非病区均有分布，且都不是优势菌；ＭＦ在克山病区和非病区粮中均有侵染，不同粮食种类毒素污染的差别大于病区与非病区之间的差别，与克山病的地区性分布特点不一致。因此，本研究结果得不出ＭＦ是克山病致病因素的结论，因而不支持“串珠镰刀菌素是克山病病因”

In order to answer the question of 'is MF the possible etiologic factor of KD?', the toxicity and the factors affected the toxicity of MF were studied, and the contamination of MF in cereals from KD affected and non affected areas were surveyed. The results indicate that 1) The target organs of MF infection are heart and testis, The target sites are mainly enzymes, such as PDH, SDH, GPX and PHGPX etc.; 2) The changes of pathology and enzymology in the MF exposed hearts were not the same as found in the heart of KD. 3) There was no relationship between the toxicity of MF and selenium (Se) status of the host. Supplementation of Se and VE has no inhibitary or reducing effect on the toxicity of MF, which is in contrast to the fact that KD can be prevented by Se supplementation; 4) The distribution of fusarium strains occur in both KD affected and non affected areas, and they were not predominant fungus; 5) The contamination of MF in cereals was detected in both KD affected and non affected areas. The differences in the distribution of MF among various cereals were greater than that between affected and non affected areas. There was no regional distribution of MF as that of KD. The results from this study can not come to the conclusion that MF is the etiologic factor of KD, and consequently do not support the hypothesis that MF is the cause of KD.