日光消除杂色曲霉素致突变作用的研究

Elimination of sterigmatocystin mutagenicity by sunlight

采用小鼠微核试验和体外人外周血淋巴细胞程序外ＤＮＡ合成试验（ＵＤＳ）探讨了日光消除杂色曲霉毒素致突变性的作用。结果表明，经日晒８ｈ，杂色曲霉培养物的提取液不能诱导微核出现率升高和ＵＤＳ；相反，未经日晒的培养物的提取液则可明显引起微核率升高和ＵＤＳ。

he elimination of sterigmatocystin (ST) mutagenicity in corn flour by sunlight exposure was studied using micronucleus test in NIH mice in vivo and unscheduled DNA synthesis test (UDS) in human peripheral blood lymphocytes in vitro. The results show that the extract solution of the aspergillus versicolor culture which was exposed to sunlight for 8 hours, induces the increase in micronucleus rate and UDS. On the contrary, the extract solution of the aspergillus versicolor culture, which was not exposed to sunlight causes significant increase in micronucleus rate and UDS. Thus, the studies indicate that sunlight could eliminate the mutagenicity of ST in grains.