刺五加制剂对小鼠的抗疲劳作用

Effect of Ciwujia(Radix Acanthopanacis Senticosus)preparation on the stamina of mice

采用小鼠游泳试验系统地研究了刺五加制剂对小鼠抗疲劳作用的影响。口服刺五加制剂0.8g/kg 剂量组与人参0.8g/kg 剂量组相当,可使游泳时间延长60%;1.6g/kg 为适宜剂量,游泳时间延长132%。无论一次给药还是持续给药,刺五加制剂均有增强小鼠运动耐力的作用(游泳时间分别延长65%和100%～120%),然而持续给药比一次给药抗疲劳效应更强。人参和冬虫夏草与刺五加制剂复合给药,均使刺五加制剂抗疲劳效应降低。

The effect of Ciwujia (Radix Acanthopanacis Senticosus) preparation on prolonging the time of exercise in mice was studied by a chronic swimming test.Oral administration of 0.8g/kg of Ciwujia preparation pro- longed the swimming time up to 60%,which was equivalent to the same dosage of ginseng extract.The proper dosage of Ciwujia preparation was 1.6g/kg,which made the swimming time prolonged by 123%.Af- ter a single dose (1.6g/kg) of Ciwujia preparation was given,the swimming time increased by 65%.How- ever,after 7 consecutive doses of 1.6g/kg for 7 days,the swimming time increased 100%～120%.The ef- fect of Ciwujia preparation on prolonging swimming time was actually reduced by combinning with ginseng extract and cordyceps extract.