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吡格列酮对血管内皮细胞增殖的抑制作用

Effect of Pioglitazone on Growth of Vascular Endothelial Cell
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摘要 目的观察吡格列酮对血管内皮细胞增殖的抑制作用。方法四唑盐比色试验(M TT法)检测吡格列酮对正常血管内皮细胞(ECV 304)生长的抑制作用。结果吡格列酮在终浓度为1×10-8mm o.lL-1-1×10-4mm o.lL-1时对ECV 304细胞的增殖具有抑制作用,而且此作用呈浓度依赖性。结论吡格列酮对ECV 304细胞具有浓度依赖性的抑制增殖作用。 OBJECTIVE To observe the effect of pioglitazone in vascular endothelial cells in vitro. METHODS The effect on growth of vascular endothelial ceils （ECV304） was determined by MTT. RESULTS Pioglitazone can inhibit the growth of vascular endothelial cells by 1 ×10^-8mmol · L^-1～× 10×^-4mmol · L^-1, and the effect was concentration-dependent. CONCLUSION Pioglitazone had the concentration--dependent inhibitory effect in endothelial cell.
作者 陈洲
机构地区 福建医科大学药学院药理教研室
出处 《海峡药学》 2006年第5期43-44,共2页 Strait Pharmaceutical Journal
关键词 血管内皮细胞 MTT 吡格列酮 Endothelial cells Pioglitazone MTT
分类号 R977.15 [医药卫生—药品]
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参考文献9

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海峡药学
2006年 第5期

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