莫西沙星治疗泌尿道感染的疗效评价

Therapeutic Evaluation of Moxifloxacin in the Treatment of Urinary Tract Infection

目的评价莫西沙星治疗泌尿道感染的临床疗效。方法采用随机、开放、平行时照试验设计。选择泌尿道感染病例195例，其中可评价病例176例，莫西沙星组（治疗组）90例，给予莫西沙星400mgqd．疗程为7～14d：左氧氟沙星组（时照组）86例，给予左氧氟沙星200ragbid。疗程为7～14d。结果莫西沙星组临床总有效率97．8％，左氧氟沙星组91．9％，两组的细菌清除率分别为96．7％和94．2％，不良反应发生率分别为7．78％和9．30％．两组比较均无显著性差异（P〉0．05）。结论莫西沙星是一种治疗泌尿道感染，高效、安全、服用方便的抗菌药物。

OBJECTIVE To estimate the clinical efficacy of moxifloxacin in the treatment ot urinary tract infection. METHODS The trial design was randon,open,and parallel control. 195 patients with urinary tract infection were involved. 176 cases evaluated were randomly divided into the treatment group or the control. 90 patients in treatment group were given 400mg moxifloxacin capsule for 7- 14d,while 86 patients in control group were given 200mg levofloxacin capsule twice a day for 7-14d. RESULTS The total clinical effective rate of case and control group were 97.8 %and 91.9% respectively,and the bacterial eliminating rate were 96.7 % and 94.2 respectively,and the rate of adverse reaction were 7.78%and 9.30% respectively. There was no a significant difference between both gioups （P〉0.05）. CONCLUSION Moxifloxacin is a very antibiotic in treating urinary tract infection with a few adverse reaction and convenient administration.