金双歧联合阿普唑仑与单用金双歧治疗肠易激综合征的随机对照研究被引量：2

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摘要目的比较金双歧联合阿普唑仑与单用金双歧治疗肠易激综合征(IBS)的效果和安全性。方法85例IBS患者随机分为两组,44例接受金双歧(2粒/次,每日3次)和阿普唑仑(1次0.4m g,1日2次)的联合治疗,41例单用金双歧(粒/次,每日3次),两组其他内科常规治疗相同,疗程4周。评估两组治疗前后IBS问卷、生活质量问卷和汉密尔登焦虑量表(HAMA)及汉密尔登抑郁量表(HAM D)评分变化。每周复诊,记录不良反应。结果治疗前,两组IBS症状、肠外症状、生活质量、汉密尔登焦虑和抑郁量表评分无显著性差异。治疗后两组IBS症状、肠外症状、生活质量治疗后均较治疗前明显改善,联合治疗组较单用金双歧组更显著。HAMA评分两药联合治疗后显著改善,但单用金双歧无明显改善。两组的HAM D评分在治疗前后均无显著改善。联合治疗组4例出现困倦等不良反应。结论金双歧联合阿普唑仑应用或者单用金双歧治疗IBS,对改善IBS症状、肠外症状、生活质量是安全有效的,联合应用效果比单独应用好。其原因可能与联合应用对改善了焦虑症状有关。

作者何洁姜贵君

机构地区厦门市第二医院消化科

出处《海峡药学》 2006年第5期128-129,共2页 Strait Pharmaceutical Journal

关键词肠易激综合征(IBS) 金双歧阿普唑仑

分类号 R969.4 [医药卫生—药理学]

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