趋化因子受体与肿瘤转移

Chemokine receptor and cancer metastasis

目前认为肿瘤细胞转移和淋巴细胞迁移具有相似机制,但趋化因子及其受体参与肿瘤转移的机制尚未完全阐明。由于其在肿瘤细胞器官选择性转移中的重要作用,趋化因子受体有希望成为肿瘤治疗的靶标并具有预后价值。现综述趋化因子受体与肿瘤侵袭和转移的研究进展。

Recent edivence indicates that chemokine receptors, particularly CXCR4, may overexpress in some tumor tissues and metastatic tissues. The mechanisms which chemokine and their receptors participate in tumor metastasis are not understand completely although many researchers believe metastasis of tumor cells and lymphocyte share the similar mechanisms. Chemokine receptors may become the hopeful targets in tumor therapy and have merits of prognosis because of their critical roles in tumor metastasis to specific organs. This review will address mainly the advancement in the relationship between chemokine receptors expressions and tumors metastasis, the corresponding mechanisms and potential merits in therapy and prognosis in recent years.