海绵动物抗肿瘤活性物质研究进展

Progress in the development of antineoplastic activity substance from marine sponge

海洋生物是抗肿瘤活性物质的重要来源。海绵动物是海洋中除珊瑚以外的第2大生物资源。近十几年来,已从不同的海绵体内分离鉴定了许多结构新颖的高活性抗肿瘤物质,显示出诱人的研究开发前景。现综述正在临床试验阶段的具有抗肿瘤活性的海绵动物提取物及其合成衍生物,以及其来源种属、化学成分及其药理作用的研究进展。

Marine organism is important source of antineoplastic active substance,sponge is the secondly larger amount of organism source besides coral in the ocean. In recent decade, several high antineoplastic active substances with novel structure are abstracted and identified from different kinds of sponges. These discovers reveal bright prospect of research and development. This article summarized antineoplastic active sponge abstracts and their synthesis derivative which still in the clinical trials ,their origins and the research development of their chemical composition and pharmacological action.