蜂毒溶血肽在肿瘤生物治疗中的研究

Progress of melittin in tumor biology therapy

蜂毒溶血肽(MLT)是意大利蜜蜂(apis mellifera)毒的主要成分之一,由26个氨基酸组成,以往临床上主要用于治疗自身免疫性疾病。但近20年来,先后发现对多种实验性肿瘤有强烈的杀灭作用,引起了人们的极大关注。现综述近年来在研究蜂毒溶血肽治疗肿瘤、提高基因转染效率等诸方面的研究进展。

Melittins, a family of peptides from honey bee （Apis mellifera） venom, have been studied as potential toxins. The major melittin species ,a 26 amino acid peptide,forms an amphipathic helix with a highly charged carboxyl terminus. It is usually used to treat autoimmune diseases. But to nearly 20 years, it acts as an anti- tumor molecule by disruption of the lipid membrane leading to leakage of intracellular contents and ultimate cell death. Also, melittin can be used as an agency to improve the gene tranfection efficiency of non-virl vector. We will review here new progress of melittin in tumor bilogy therapy.