胃癌高发区饮水对体外长期培养人胚胃成纤维细胞的影响

The Effects on Human Embryo Fibroblasts in Vitro Treated with Drinking Water in High Risk Area of Gastric Cancer

胃癌高发区饮水作用于体外长期培养的人胚胃成纤维细胞后，ＦＣＭ分析发现Ｓ和Ｇ２Ｍ期细胞比例和增殖指数明显增加，ＤＮＡ指数超出正常范围，细胞有明显的形态学改变，这些结果提示该县饮水可能有致癌性，可能与当地胃癌高发有密切关系。

The effects of drinking water in high risk area of gastric cancer on human embryo fibroblasts in vitro were analysed with Flow Cytometry. The results showed that the ratio of cell numbers of S and G 2M phase to cell population, the proliferation index in the test groups administered with the drinking water in high risk area were significantly increased and greater than that in the control groups with highly significant differences. The values of DNA index went beyond the normal range.There were some atypical changes in the test groups in morphological aspects.These indicated that the drinking water was carcinogenic and was closely correlative with the high incidence of gastric cancer.