运动对单羧酸转运蛋白的影响

Effect of sports on monocarboxylate transporter

目的:就近年来国内外关于单羧酸转运蛋白的基础研究,以及运动训练中乳酸的生成以及单羧酸转运蛋白表达的实验研究,分析运动对单羧酸转运蛋白的影响。资料来源:应用计算机检索Medline1997-01/2005-05与单羧酸转运蛋白相关文献,检索词“sport,MonocarboxylateTransporter”,并限定文献语种为“English”。同时计算机检索中文期刊网1995-01/2005-05与乳酸转运相关蛋白的文献,检索词“乳酸,单羧酸转运蛋白”,并限定文献语种为中文。资料选择:对检索到的210余篇文献进行筛选,从资料中选取关于完成乳酸转运的单羧酸转运蛋白基础研究的文献,并选择不同运动引起单羧酸转运蛋白变化的研究。以近3年且发表在较权威杂志者优先。资料提炼:共收集到20篇关于单羧酸转运蛋白对乳酸转运的基础研究和27篇关于不同运动对单羧酸转运蛋白的影响的实验研究。其中18篇纳入标准。排除的29篇中19篇是不同程度上重复的同一研究,10篇为在内容上与题目相关性较小。资料综合:18篇文献共包括480例观察对象,说明单羧酸转运蛋白能对细胞内乳酸进行跨膜转运;且耐力训练和大强度训练都能提高骨胳肌肌细胞膜上MCT1的浓度。结论:运动训练对于提高乳酸和氢离子的转运有良好作用。适度的运动训练提高糖尿病、心肌梗死患者骨骼肌单羧酸转运蛋白的含量,有助于某些疾病的治疗。

OBJECTIVE： Based on the basic studies about monocarboxylate transporter, and the laboratorial studies about synthesis of lactic acid and expression of monocarboxylate transporter in sport training at home and abroad to explore the effect of sports on monocarboxylate transporter. DATA SOURCES： A computer-based online search of Medline database was undertaken for articles about monocarboxylate transporter published in English between January 1997 and May 2005 with the key words of ＂sport, monocarboxylate transporter＂. Meanwhile, we searched the CNKI for articles published in Chinese between January 1995 and May 2005 with the key words of ＂lactic acid, monocarboxylate transporter＂ in Chinese. STUDY SELECTION： After preliminary selection of the 210 literatures, those basic researches on monocarboxylate transporter completed lactic acid transport and the change of monocarboxylate transporter caused by different sports were selected. The literatures published on authoritative magazine in recent 3 years were perferred. DATA EXTRACTION： Altogether 20 literatures about monocarboxylate transporter transporting lactic acid and 27 experimental literatures about the effect of different sports on monocarboxylate transporter were collected, in which 18 articles met the inclusive criteria. Among the 29 excluded literatures, 19 ones were to different degrees the repetitive studies and 10 ones were little related to subjects. DATA SYNTHESIS： 480 experimental objects are involved in the 18 literatures, indicating monocarboxylate transporter can transport intracellular lactic acid; moreover, the concentration of MCT1 on skeletal muscle cellular membrane can be enhanced by resistance training and high intensive training. CONCLUSION： Sport exercise has advantages in enhancing transport of lactic acid and H^＋. Appropriate exercise can enhance the concentration of monocarboxylate transporter existed in skeletal muscle of patients with diabetes or myocardial infarction, which is helpful to treatment of some disease.