可溶性转铁蛋白受体在运动医学中的应用

Application of soluble transferrin receptor in sports medicine

目的:总结可溶性转铁蛋白受体在促红细胞生成素检测、高原训练的效果评价和运动性贫血的监测方面的作用。资料来源:应用网络www.ncbi.nlm.nih.gov/PubMed检索1999-01/2004-12国内外有关可溶性转铁蛋白受体在促红细胞生成素检测、高原训练的效果评价和运动性贫血的监测中的应用方面的相关文献,检索词:solubletransferrinreceptor,sportsmedicine,erythropoietindetection,altitudetraining,sportsanemia。限定文章语种为“English”。同时在中国期刊网上检索2001-01/2005-06相关中文文献,检索词:可溶性转铁蛋白受体,运动医学,促红细胞生成素检测,高原训练,运动性贫血。资料选择:选择有关可溶性转铁蛋白受体在促红细胞生成素检测、高原训练的效果评价和运动性贫血监测中应用的文献83篇,未排除非随机研究原著性文献和非盲法研究原著性文献。资料提炼:在的83篇文献中,内容不同程度重复的有37篇,给予删除,对剩下的46篇进行分类整理,用于综述,其中18篇选为参考文献。资料综合:组织细胞摄取铁是通过血液中携带铁的转铁蛋白与细胞表面的转铁蛋白受体介导的。可溶性转铁蛋白受体是存在血清中完整的转铁蛋白受体单体的截断形式,与体内细胞的铁代谢和红细胞的生成有密切关系。可溶性转铁蛋白受体能准确反映出机体内红细胞生成的能力和缺铁的情况,故临床上在缺铁性贫血的检测和治疗效果评价中应用较多。除机体内红细胞生成的能力和铁储备状态外,其他因素对可溶性转铁蛋白受体的影响很小,相对稳定,运动对其浓度的影响也甚微。结论:可溶性转铁蛋白受体在重组人促红细胞生成素检测、高原训练效果的评价和缺铁性贫血的监测中具有重要价值,相关的研究需进一步深入。

OBJECTIVE： To summarize the application of soluble transferring receptor （sTfR） in erythropoietin detection, evaluation of altitude training and monitoring of sports anemia. DATA SOURCES： An online search of www.ncbi.nlm.nih.gov/PubMed was undertaken by using the key words of ＂soluble transferrin receptor, sports medicine,erythropoietin detection,altitude training,sports anemia＂ to identify the relevant articles of the application of sTiR in erythropoietin detection, evaluation of altitude training and monitoring of sports anemia published from January 1999 to December 2004 in Engiish： Meanwhile, Chinese Journals Full-Text Database （CJFD） were scanned to search relevant articles published from January 2001 to June 2005 with the key words of ＂soluble transferrin receptor,sports medicine,erythropoietin detection ,altitude training,sports anemia＂ in Chinese. STUDY SELECTION： Totally 83 relevant articles about the application of sTfR in erythropoietin detection, evaluating of altitude training and monitoring of sports anemia were selected. Non-randomized original papers and non-blinded papers were not excluded. DATA EXTRACTION： Among the 83 papers, 37 were deleted because they were repeated in various degrees, and the rest 46 were classified for review, and 18 of them served as references. DATA SYNTHESIS： Iron transport in the plasma was carried out by transferrin, which donated iron to cells through its interaction with the TfR. The sTfR was a truncated monomer of tissue receptor, which is related with metabolism of iron and production of red blood cell, The sTfR could exactly reflect the production ability of red blood cell and iron deficiency, so it was frequently used in the detection and therapeutic efficacy of iron deficiency anemia in clinic, With the exception of production ability of red blood cell and iron deposit, other factors had little effects on sTfR, stable, and the influence of sports on its concentration was also slight. CONCLUSION： The sTfR plays an important role in erythropoietin detection, evaluating of altitude training and monitoring of iron deficiency anemia, and relevant study should be further reinforced,