骨移植替代物医用硫酸钙初步临床应用

CLINICAL APPLICATION OF MEDICAL GRADE CALCIUM SULFATE AS A BONE GRAFT SUBSTITUTE

目的 观察医用硫酸钙（Osteoset颗粒）作为骨移植材料的临床应用效果。方法 2004年12月～2005年5月，采用Osteoset颗粒作为骨移植材料治疗9例四肢良性肿瘤性骨缺损（四肢组），其中肱骨黄色纤维瘤1例，髋臼黄色纤维瘤2例，肱骨骨囊肿1例，桡骨骨囊肿1例，股骨非骨化性纤维瘤1例，股骨骨化性纤维瘤1例，股骨骨纤维结构不良2例。同期将材料作为自体骨增量物用于5例腰椎后外侧融合术患者（脊柱组），其中腰椎管狭窄症2例，腰椎滑脱症2例，腰椎峡部裂1例。通过影像学方法评估Osteoset颗粒的成骨作用。结果 14例患者平均获随访6．2个月（3～9个月），Osteoset颗粒植入后1～3个月开始吸收，4～6个月完全吸收并被骨组织替代。四肢组患者术后骨肿瘤无局部复发，肢体功能恢复良好；脊柱组患者术后6个月均获骨性融合。结论 医用硫酸钙是一种成骨性能优良的骨移植材料。

Objective To investigate the clinical effect of medical grade calcium sulfate（Osteoset） as a bone graft substitute. Methods From December 2004 to May 2005, 9 cases of bone defect（limb group） were repaired with Osteoset pellets; bone defect was caused by benign tumor in limbs, including 3 cases of fibroma xanthomas in humerus （1 case） and acetabulum （2 cases）, 2 cases of bone cysts in humerus（1） and radius（1）, 1 case of nonossifying fibroma, 1 case of ossifying fibroma and 2 cases of osteofibrous dysplasia in femurs. Five cases of lumbar posterolateral fusion （spine group） were treated with Osteoset pellets as autograft volume expander, including 2 cases of lumbar spinal stenosis, 2 cases of lumbar spondylolisthesis and 1 case of lumbar spondylolysis. Radiological method was used to evaluate the repair effect of Osteoset pellets. Results The mean follow-up time was 6. 2 months （3 to 9 months）. Osteoset pellets began to be absorbed after 1 to 3 months of operation, and were totally absorbed and replaced by osseous tissue after 4 to 6 months. No local recurrence was detected in limb group and the function of limbs was normal. At 6 months after operation, all patients in spine group got bony fusion. Conclusion Medical grade calcium sulfate （Osteoset） is an ideal bone graft substitute with excellent bone repair effect.