挑治法治疗毒性弥漫性甲状腺肿疗效观察

Observation on therapeutic effect of picking therapy on Graves'disease

目的:观察挑治法对毒性弥漫性甲状腺肿(GD)的治疗作用和对甲状腺功能的影响。方法:60例GD患者随机分为治疗组(针挑组)和对照组(药物组),分别采用针挑甲状腺高点或口服药物他巴唑治疗。观察三碘甲状腺原氨酸(TT3)、甲状腺素(TT4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺素受体抗体(TRAb)、超敏促甲状腺素(S-TSH)变化。结果:治疗组和对照组总有效率分别为93·33%和76·67%(P<0·05)。两组治疗后血清TT3、TT4、FT3、FT4、S-TSH改变非常显著(P<0·01);治疗组TRAb改变有非常显著性意义(P<0·01),但对照组无显著性意义(P>0·05);两组间在降低TT3、FT3、TRAb上有明显差异(P<0·05),但在降低TT4、FT4及升高S-TSH上没有明显差异(P>0·05)。结论:针挑疗法治疗GD有确定的疗效,通过调节甲状腺功能达到治疗目的。

Objective To observe therapeutic effect of picking therapy on Graves＇ disease （GD） and its effects on thyroid function. Methods Sixty cases of GD were randomly divided into a treatment group （pricking therapy group） and a control group （medication group）. They were treated respectively with pricking thyroid gland high point or oral administration of tapazole. And changes of total triiodothyronine （TT3）, total thyroxine （TT4）, free T3 （FT3）, free T4 （FT4）, thyroxine receptor antibody （TRAb）, supersensitive thyrotropin （S-TSH） after treatment were investigated. Results The total effective rate was 93. 33% in the treatment group and 76.67% in the control group with a significant difference between the two groups （P〈0. 05）. After treatment, serum TT3, TT4, FT3, FT4 and S-TSH contents had very significant change in the two groups （P〈0. 01）, TRAb had very signifi- cant change in the treatment group （P〈0. 01） and no significant change in the control group （P〉0. 05）; there were significant differences in decrease of TT3, FT3, TRAb （P〈0. 05） and no significant difference in decrease of TT4, FT4 and increase of S-TSH between the two groups （P〉0. 05）. Conclusion Pricking therapy has a definite therapeutic effect on Graves＇ disease, which is carried out through regulating thyroid function.