高频超声结合eFlow显像评价系统性红斑狼疮患者指端微血管血流的初步探讨

Assessing the fingertip's vascular of patients with systemic lupus erythematosus by high frequency ultrasonography combined with eFlow imaging:initial exploration

目的探讨高频超声结合eFlow显像技术评价系统性红斑狼疮(SLE)患者指端微血管血流的临床价值。方法SLE患者未治疗组14例,治疗组17例,正常对照组32例。使用高频超声eFlow显像显示右手中指末节指腹和甲床内微血管的走行和分布,并计算甲床内血管-甲床像素比。结果①eFlow显像可清晰、连续显示正常组末节指腹的血管分支、吻合支及甲床血管网。②SLE患者指端血流显像欠清晰、连续性较差,血流分布减少,以未治疗组尤为显著。③正常组、治疗组及未治疗组的血管-甲床像素比呈递减趋势,其间差异有统计学意义(P<0.05)。结论高频超声结合eFlow显像技术为探测SLE患者指端微血管血流,提供了一种敏感性高,空间分辨率好的新方法。

Objective To explore the value of assessing the fingertip＇s small vascular flow of patients with systemic lupus erythematosus （SLE）. Methods All the examinees were divided into 3 groups： group Ⅰ （normal control, 32 cases）, group Ⅱ （SLE patients treated with glucocorticoid or immunosuppressant, 17 cases）, group Ⅲ （untreated SLE patients, 14 cases）. High frequency ultrasonography combined with eFlow imaging was used to display the course and distribution of small vessels at middle fingertip of the right hand. And then the ratio of pixels in vascular and nail bed was calculated. Results （1） In normal control group, the branches, ramus anastomoticus and vascular net of fingertip could be displayed clearly and continuously by eFlow imaging. （2）To SLE patients, especially in group Ⅲ , the definition and continuity of fingertip＇s small vascular flow images was not as good as that in normal control group, and the distribution of blood flow decreased. （3）In group , group 0282 and groupⅢ , the ratio of pixels in vascular and nail bed showed the trend of decrease, and statistical differences were found among ratios from three groups （P〈0.05）. Conclusion High frequency ultrasonography combined with eFlow imaging provide a high-sensitive and nice-resolution tool to detect fingertip＇s small vascular flow in the patients with SLE.