摘要
目的:探讨房间隔缺损(ASD)患者介入治疗前后心肌肌钙蛋白I(cTnI)的变化规律。方法:42例ASD患者(ASD组)、16例诊断性导管介入的先天性心脏病患者(诊断性导管介入组)用酶联免疫吸附(ELISA)法检测介入前后不同时间点血清cTnI的水平。结果:所有患者术前血清cTnI水平处于正常值范围内;术后即刻、4 h及24 h,ASD组较术前升高,诊断性导管介入组与术前无差异,两组间有显著统计学意义(P<0．01);72 h两组间无显著统计学意义(P>0．05)。结论:ASD的介入治疗引起可逆性的心肌微损伤,是一种安全、有效、创伤小的方法。
Objiective. To observe the changes of cardiac troponin l（cTnl） after interventional closure of atrial septal defects. Methods：cTnl level was measured by ELISA in 42 patients with atrial septal defects（ ASD）and I6 comgenital heart desease （CHD） patients undergoing diagnostic catheterization, before, immediately, and 4,24,72 hours after intervention,
Results ： All the ASD patients, had a serum cTnl level before intervention. The cTnl level was significantly increased immedi- ately and 4,24 hours after intervention comparied with CHD patients （P 〈 0. 01 ）. At 72 h no difference in cTnl was found between two groups （ P 〉 0. 05 ）.
Conclusion ： Transcatheter closure of atrial septal defects may result in reversible, minor myocardial damage. However it is a safe, effective and ideal method.
出处
《中国循环杂志》
CSCD
北大核心
2006年第5期376-378,共3页
Chinese Circulation Journal
关键词
房间隔缺损
心肌肌钙蛋白I
介入治疗
Atrial septal defects
Aardiac troponin 1
Transcatheter closure
