影响血清地高辛浓度因素的调查分析

Investigation and analysis of factors affecting on serum-digoxin concentration

目的:探讨我院应用地高辛的现状及影响血清地高辛浓度的因素。方法:收集2005年我院861例次血清地高辛浓度数据,并采用多元回归方法分析血清地高辛浓度和年龄、性别、血清肌酐浓度、剂量等因素的关系。结果:年龄(age)、性别(sex)、血清肌酐浓度(Scr)及剂量(dose)等4因素均对血清地高辛浓度(con)有影响(P<0.05),经多元回归分析它们的关系可以表达为:con=-0.474+0.750×dose+0.154×Scr+0.128×sex+0.003×age。结论:血清地高辛浓度个体差异较大,影响血清地高辛浓度有多种因素。对于大多数患者服用地高辛的剂量不宜>0.125mg/d,如果血清肌酐值偏高,提示患者可能有肾功能减退,应该减量服用地高辛。对于女性患者更应该仔细调整剂量,以免出现地高辛中毒。

Objective. To investigate and analyse the situation of digoxin used in our hospital and the factors affecting on serum-digoxin concentration. Methods： Eight hundred and sixty-one data of serum-digoxin concentration were collected in our hospital in 2005. The relationship between serum-digoxin concentration and the factors including age ,sex, serum-creatine concentration was analysed by multivariate regression analysis. Results： The serum-digoxin concentration was affected by the four factors of age, sex, serum- creatine concentration, and the dose （P≤ 0.05）. The relationship between them were con= -0.474＋0.750×dose＋0.154× Scr＋0.128×sex＋0.003×age by multivariate regression analysis. Conclusion： Serum-digoxin concentration varies with individuals and is affected by many factors. As regards most patients, the dose ofdigoxin should not be over 0.125 mg daily. If the serum-creatine concentration exceed the normal range, it is likely to be renal dysfunction to the patient. In such a case, the dose of digoxin should be reduced. As regards women, the dose of digoxin should be carefully adjusted to avoid digoxin toxicity.