摘要
采用ABC免疫组织化学方法对41例胃癌组织,66例正常胃和良性病变胃组织内癌胚抗原表达作了研究。结果显示;胃癌组织内癌胚抗原(CEA)的表达程度明显强于正常胃和良性病变胃组织;前者CEA的分布形式多呈胞浆型和间质型,而后者则呈腔缘型和膜型。同时表明组织内CEA的分布形式与肿瘤细胞的生长方式和浸润深度有关。作者认为组织内CEA的表达状况与胃癌细胞生物学行为有关,其在组织内的分布形式较其含量更为重要,相同组织学类型CEA亦可有不同的分布形式。
Carcinoembryonic antigen (CEA)was measured with ABC immunohistochemistry method in fourty-one gastric cancer tissues and sixty-six tissue from normal stomach and gastric benign lesions. The study revealed that the reactive signals in the former were stronger than those in the latter. Simultaneously, CEA localized mainly in the cytoplasm or stroma in the cancerous tissue,but in normal gastric tissue or benign gastric lession,CEA distributed mainly in the margin of gland with gastric depression or membranous type. The result also revealed that the distribution patterns of ECA were linked with the cell growth types and infiltrating of gastric cancer.,The authors consider that the expression state of CEA in gastric cancer is correlated with its biological behavior,and distribution patterns of CEA are more clinically significant than reactive intensities in the tissue. Patients have different prognosis with different CEA distribution patterns in tissue though their pathological types and TNM stages are the
关键词
癌胚抗原
胃癌
生物学行为
Carcinoembryonic antien Gastric Cancer Biological behavior
