黄芪注射液对冠状动脉作用的研究

Effects of Astragalus Membranaceus on the Spiral Strips of Porcine Coronary Artery

本文利用生物检定法，观察黄芪对猪冠脉螺旋肌条的作用。研究表明：黄芪注射液可以拮抗ＫＣｌ和组胺所致冠脉的收缩。表现为先给予不同浓度黄芪后，两者的致收缩曲线明显压低，并呈量效关系。在ＫＣｌ和组胺引起冠脉条收缩达最大效应时，黄芪可阻断它们的收缩。结果提示：黄芪有直接扩张冠脉效应，临床可用来治疗冠脉痉挛引起的疾病，用于预防效果更佳。

Bioassay was used to study the effects of Astragalus Membranaceus(AM)on spiral strips of porcine coronary artery. The results showed that AM inhibited contraction of strips induced by KCl and histamine. AM(20-80mg/ml)was added respectively into the medium 30s prior to the induction by KCl and histamine, and the their contraction curve decreased significantly in a dose-dependent manner. AM also blocked the contraction of strips induced by KCl and histamine. The results indicate the AM might dilate coronary artery directly. It is thought to be effective in the treatment and,in particular, prevention of the angina caused by coronary artery spasm.