辅酶Q_（10）对超量醋氨酚所致急性肝损伤的保护作用观察及机理探讨

Study of Protective Effect of CoQ_(10) on Hepatic Damage Caused by Overdosage of Acetaminophen in Mice

本文报道辅Ｑ１０（ＣｏＱ１０）对超量ＡＡＰ引起小鼠急性肝损伤的保护作用。结果表明，预先给小鼠皮下注射ＣｏＱ１０，能对抗用量醋氨酚（ＡＡＰ）所致的肝糖原含量下降和肝损伤引起的ＳＡＬＴ活性升高及病理组织学变化；同时也发现ＣｏＱ１０。能使血清ＡＡＰ浓度和肝匀浆谷膦甘肽（ＧＳＨ）含量高于对照组。这说明ＣｏＱ１０对超量ＡＡＰ所致的急性肝损伤确有保护作用。从后三项实验结果来看，ＣｏＱ１０有间接稳定肝细胞膜的作用，使ＡＡＰ毒性中间代谢产物生成减少。

The protective effect of coenzyme Q10 on liver damage in mice induced by the overdosage of Acetaminophen is reported. The results showed that CoQ10 decreased the activity of SALT, increased hepatic glycogen and ameliorated the pathological changes of hepatic damage due to overdosage of Acetaminophen in mice. It was also indicated that CoQ10could cause the increase of serum Acetaminophen concentration and glutathione content but did not change the content of hepatic microsome cytochrome P450. It could be concluded that the mechanism of CoQ10 protective effect on hepatic damage induced by the overdosage of Acetaminophen might be regarded as the increase of stability of hepatic membrane and microsome membrane.