Survivin与Ki-67在尖锐湿疣中的表达及其相互关系

THE EXPRESSION SURVIVIN AND KI-67 ANTIGEN IN CONDYLOMA ACUMINATUM AND THE CORRELATION BETWEEN THEM.

目的:探讨凋亡抑制基因(Survivin)和增殖相关核抗原(Ki-67抗原)在尖锐湿疣(CA)组织中的表达情况及其相互关系。方法:用SP免疫组化法检测Survivin及Ki-67蛋白在60例CA组织、15例正常宫颈上皮组织中的表达情况。结果:Survivin和Ki-67在CA中的阳性率分别为55.0%和91.7%。CA组中Survivin和Ki-67表达的阳性率与正常对照组比较差异有统计学意义,且CA中两者的阳性率呈明显的正相关(P<0.05)。结论:Survivin和Ki-67与CA的发生发展密切相关,且两者在CA中的表达具有一定的协同性。

Objective： To investigate the expression of Survivin and Ki - 67 Antigen in Condyloma Acuminatum （CA） and the correlation between them.Methods： The expression of Survivin and Ki- 67 were measured by immunohistochemical technique in 60 cases of CA and 15 cases of normal squanaous epithelia of cervix.Result： The positive expression percentage of Survivin and Ki - 67 in CA were 55.0% （33/60） and 91.7% （55/60） respectively.The expression of Survivin and Ki - 67 in CA were significantly higher than that in normal squamous epithelia of cervix. The expression of Survivin was positively correlated with the high expression of Ki - 67 in CA. Conclusions： Survivin and Ki-67 might play important roles in the development of CA, and their expression in CA are synergetic .