摘要
目的研究竹节参总皂苷对中动脉栓塞模型大鼠血液流变学的影响,进一步明确其阻抑脑缺血损伤的作用机理。方法建立大鼠永久性中动脉栓塞模型(MCAO),观察竹节参总皂苷对模型大鼠红细胞变形性、聚集性、血液粘度的影响。结果竹节参总皂苷(200、100、50mg/kg)能显著降低中动脉栓塞模型大鼠全血粘度、红细胞聚集性,增加红细胞变形性。结论竹节参总皂苷对脑缺血损伤的保护作用可能与其改善中动脉栓塞模型大鼠血液流变学指标有关。
Objective To study the effect of total rhizoma panacis japonica saponins （tRPJS） on hemorheology in rats with occlusion of the middle cerebral artery. Methods Ischemia rat models were made by using the method of thread inserting right middle cerebral artery occlusion. The effects of tRPJS on whole blood viscidity, erythrocyte deformability and erythrocyte congregate in model rats were observed. Results tRPJS 200, 100, 50 mg/kg could significantly improve the erythrocyte deformability, reduce whole blood viscidity and erythrocyte congregate. Conclusion tRPJS can improve the hemorheology after cerebral ischemia. It may be one of the mechanisms for tRPJS in treating ischemic stroke.
出处
《中国中医药信息杂志》
CAS
CSCD
2006年第11期33-34,共2页
Chinese Journal of Information on Traditional Chinese Medicine
基金
北京市优秀人才资助项目(20051D0501823)
关键词
大鼠
竹节参总皂苷
血液流变学
脑缺血
total rhizoma panacis japonica saponins （tRPJS）
hemorheology
cerebral ischemia
