2,3-联烯醇及其衍生物的反应

Reactions of 2,3-Allenols and Their Derivatives

2,3-联烯醇是一类含1,2-二烯官能团和羟基的化合物,具有很高的反应活性,它及其衍生物是一类重要的联烯化合物．概述了2,3-联烯醇及其衍生物的反应,包括2,3-联烯醇在过渡金属催化下的自身异构环化反应、钯催化的偶联反应、钉催化的环羰基化反应、不同条件下不同方式的扩环反应、亲电试剂参与的反应、分子内环加成反应、自由基反应等和2,3-联烯醇衍生物在零价钯催化下基于亚甲基-π-烯丙基钯中间体生成联烯或1,3-共轭二烯的区域选择性反应, SN2'类型的加成-消除反应,二价钯催化下的分子内环化反应以及重排反应等．

2,3-Allenols, an important class of aUenes containing a 1,2-propadiene unit and a hydroxy group, are highly reactive. The reactions of 2,3-allenols and their derivatives are reviewed. The reactions of 2,3-allenols include transition metal-catalyzed cycloisomerization reactions, Pd-catalyzed coupling reac- tions, ruthenium-catalyzed cyclic carbonylation reactions, ring expansion reactions, electrophilic addition reactions, cycloaddition reactions, and radical reactions. On the other hand, the reactions of the derivatives of 2,3-allenols are Pd（0）-catalyzed reactions involving methylene-π-allyl palladium intermediates forming allenes or 1,3-dienes regioselectively, SN2＇ type addition-elimination reactions, Pd（Ⅱ）-catalyzed intramolecular cyclizations and rearrangement reactions.