羊肚菌水提物对急性肝损伤的干预作用

Protective Effects of Morchella esculenta on Acute Hepatic Injury Induced by CCl_4 in mice

研究羊肚菌水提物对CCl4致小鼠急性肝损伤的保护作用。预防给药16d后,采用CCl4复制小鼠急性肝损伤模型,24h后,眼眶取血,测定血清中丙氨酸氨基转移酶(ALT)、超氧化物歧化酶(SOD)、丙二醛(MDA)以及血清蛋白的变化,观察羊肚菌水提物对急性肝损伤的保护作用。羊肚菌水提物能明显降低模型组的血清转氨酶、肝脂质过氧化物含量抑制蛋白流失及肝脏肿大。说明羊肚菌水提物对小鼠肝脏的化学损伤有显著的保护作用。

To study the protective effects of Morchella escuIenta on acute hepatic injury induced by CCl4 in mice.Pretreated with the extract from Morchella esculenta for 16 days,mice modles of acute hepatic injury were established by the treatment of carbon tetrachloride （CCh） .After 24 hours,the protective effects of the extract from Morchella esculenta in acute hepatic injury were observed through determing the activities of alanine aminotransferase （ALT） , （SOD） , Maleic Dialdehyde （MDA） ,and the contents of proteins in serum. The extract from Morchella esculenta significantly reduce the level of serum ALT, MDA and the hepatic index, and increasing SOl） activity, level of serum protein. It has showed that Morchella esculenta has proactive effects on mice acute hepatic injury.