重症肌无力合并胸腺瘤的临床特点及细胞核增殖相关抗原的表达

Features of myasthenia gravis with thymoma and randomized controlled study of PCNA expression in thymoma

目的探讨重症肌无力(MG)合并胸腺瘤的临床特点和细胞核增殖相关抗原(PCNA)的表达。方法选择25例伴有MG的胸腺瘤患者(MG组)和25例不伴有MG的胸腺瘤患者(非MG组),采用免疫组化法检测患者胸腺瘤组织中PCNA的表达,阳性为棕黄色颗粒;记录在放大100倍的油镜下随机计数1000个肿瘤细胞中的阳性细胞率。结果MG组中5例发生肌无力危象,其中1例死亡。伴重症肌无力的瘤性细胞群主要含有PCNA低表达的细胞。结论伴重症肌无力的胸腺瘤组织恶性程度相对较低,淋巴细胞型的胸腺瘤患者易伴发重症肌无力。

Objective To investigate the pathogenesis of MG with thymoma by randomized controlled study of PCNA expression in thymoma. Methods The immunohistochemical staining with PCNA was performed on 50 specimens. Results There was low PCNA expression in most specimens of thymoma with MG. Conclusions It is clear that thymoma with MG is more benign than control. LP type is prone to have myasthenia gravis.