门脉高压性胃病患者胃黏膜Ghrelin的表达

Expression of Ghrelin in gastric mucosa of patients with portal hypertensive gastropathy

目的研究Ghrelin在门脉高压性胃病(PHG)胃黏膜上的表达。方法用免疫组化方法检测36例门脉高压患者和15例对照组(内镜检查胃黏膜大致正常)胃黏膜Ghrelin的表达。结果门脉高压组胃黏膜Ghrelin表达阳性细胞面积(18.89%±5.47%)与对照组(8.51%±5.31%)比较,差异有显著性(P<0.001);PHG组胃黏膜Ghrelin表达阳性细胞面积(20.82%±6.35%)与单纯门脉高压症(PHT)组(17.51%±4.40%)比较有增高趋势,但无显著性差异(P>0.05)。结论Ghrelin可能参与了门脉高压时高动力循环的形成和发展,分泌Ghrelin的内分泌细胞对PHG时胃黏膜损害具有相当的抵抗力。

Objective To investigate the expression of Ghrelin in gastric mocosa of portal hypertensive gastropathy （PHG）. Methods The specimens were obtained from the gastric mucosa of 36 patients with portal hypertension and 15 control subjects undergone negative endoscopy. The expression of Ghrelin in biopsy specimens were detected by immunohistochemistry, Results The percentage of Ghrelin- positive cells in gastric mucosa of patients with portal hypertension was significantly higher than that in the controls （ 18.89% ± 5. 47% vs 8. 51% ± 5.31%, P 〈 0. 001 ）. Although the percentage of Ghrelin-positive cells in PHG was higher than that in PHT without PHG,there was no prominently statistical difference between the two groups （ P 〉 0.05 ）, Conclusions Ghrelin may contribute to the formation and the development of hyperdynamic circulation in PHT. The gastric endocrine cells responsible for Ghrelin synthesis were fairly resistant to gastric lesions stimulated by PHG.