期刊文献+

大肠癌中金属硫蛋白检测的临床意义

下载PDF
导出
摘要 目的:探讨MT在大肠癌中表达状况及意义。方法:利用SP免疫组化方法,检测了74例大肠癌标本。结果:MT在大肠癌中的阳性率为59.46(44/74),并且在高分化癌组阳性率明显高于低分化组,癌侵犯浆膜组阳性率高于浅肌层组。结论:MT在大肠癌中有较高表达。其阳性率与分化程度和癌侵犯深度有相关性。检测癌组织MT,对制定化疗方案有指导意义。
出处 《陕西医学杂志》 CAS 北大核心 2006年第11期1448-1449,共2页 Shaanxi Medical Journal
  • 相关文献

参考文献7

二级参考文献21

  • 1Raymond E,Chaney S G,Taama A,et al. Oxaliplatin:A review of preclinical and clinical studies[J].Ann Oncol,1998,9(10):1053-1071.
  • 2Levi F,Misset J L,Brienza. Achronopharmacologic phaseⅡclinical tial with 5-fluorouracil,folinicacid,and oxaliplatin using an ambulatorymultichannel programmable pump:high antitumor effectiveness against metastasis colorectal cancer[J].Cancer,1992,69(4):893-900.
  • 3Levi F,Perpoint B. A multicenter phaseⅡtrial of intensified chronotherapy with oxaliplatin,5-fluorouracil and folinic acid in padents with previous untreated metastatic colorectal cancer(Abstr)[J].Proc Am soc clin oncol,1997,16(5):266.
  • 4Richard H,Wilson,Tanya lehky,Rebecca R.Thonas.Acute Oxaliplatin-induced peripheral Nerve Hyperexcitability[J].Journal of clinical oncology,2002,20(16):3561-3562.
  • 5Misset J L,Brienza S,Taamma A. Pharmacokinetics,urinary and fecal excretion of oxaliplatin in cancer patients[J].Am Ass Cancer Res Meeting abstract,1996,5(37):1252-1255.
  • 6Grolleau F,Gamelin L,Boisdron-celle M,et al. A possible Explanation for a Neurotoxic Effect of the Anticancer agent oxaliplatin on Neuronal Volgage-Gated Sodium channels[J].The American Physiological Society,2001,85(5):2293-2297.
  • 7Mckeage M J,Hsu T,Screnci D. Nucleolar damage correlates with neurotoxicity induced by different platinum drugs[J].British journal of Cancer,2001,85(8):1219-1225.
  • 8Cascinu S,Catalano V,Cordella L,et al. Neuroprotective effect of reduced glutathione on oxaliplatin-based chemothera in advanced colorectal cancer:a randomized,double-blind,placebo-controlled trial[J].Clin Oncol,2002,20(16):3478-3483.
  • 9Allain P,Heudi O,Cailleux A. Early biotransformations of oxaliplatin after its intravenous administration to cancer patients[J]. Drug Metab Dispos,2000,28(11):1379-1384.
  • 10Rossman T G ,Goncharova E I. Spontaneous mutagenesis in mammalian cells is caused mainly by oxidative events and can be blocked by antioxidants and metallothionein[J]. Mutat Res, 1998,402(1-2):103-110.

共引文献39

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部