结直肠癌患者血清MIC-1的表达及意义

Expression of significance macrophage inhibitory cytokine 1 in colorectal carcinoma

目的评价结直肠癌患者血清中巨噬细胞抑制因子1(M IC-1)的表达水平及其临床意义。方法测定152例未经放化疗结直肠癌患者及120例健康对照组的血清M IC-1、癌胚抗原(CEA)及糖链抗原19-9(CA 19-9)水平。结果结直肠癌患者血清M IC-1水平较健康对照组显著升高(P<0.01),M IC-1水平与Dukes分期、分化程度、浸润深度、淋巴转移、远处转移相关(P<0.01),与年龄、组织类型无关。M IC-1表达与CEA呈正相关(r=0.514;P<0.01),联合CEA及CA 19-9检测可提高结直肠癌诊断的敏感性和准确率。结论血清M IC-1联合CEA及CA 19-9对结直肠癌诊断和鉴别诊断有一定的临床应用价值。

[objective] To evaluate the expression of macrophage inhibitory cytokine 1 （MIC-1） in colorectal carcinoma and its clinical significance. [Methods] MIC-1,CEA and CA19-9 serum levels were determined in 152 patients with colorectal carcinoma without radiotherapy or chemotherapy and 120 normal subjects. [Results] There was a significant increase in serum MIC-1 levels in colorectal carcinoma group compared with normal controls （P〈0. 01）. Serum MIC-1 level was correlated with Dukes stage, the level was higher in patients with higher Dukes stage, serum MIC-1 level had correlation with differentiation, infiltration extent, lymph node metastasis, distant metastasis （P〈0. 01）, and no correlation with MIC-1 levels and age, tissue category. Serum MIC-1 was positive correlated with CEA （P〈0. 01; r= 0. 514）, and combinations of CEA and CA19-9 can increase sensitivity and accuracy of colorectal carcinoma detection. [Conclusion] Serum MIC-1 measurement combined with CEA and CA19-9 can aid in diagnosis and differential diagnosis of colorectal carcinoma.