2-氧代-2-[1-(3-吡啶甲基氨基)-1′-芳基]甲基-4-芳基-5,5-二甲基-1,3,2-二氧磷杂环己烷的合成与生物活性

Synthesis and Biological Activities of 2-oxo-2-[1-(3-pyridylmethylamino)-1′-aryl]methyl-4-aryl-5,5-dimethyl-1,3,2-dioxaphosphinane

采用环状亚磷酸酯与亚胺的加成反应,合成了9个未见文献报道的含吡啶基的α-氨基环状膦酸酯化合物.其结构经1H NMR,31P NMR,MS和元素分析确证,同时采用X射线单晶衍射对化合物3i的立体构型进行了进一步确证.测定了该系列化合物的杀虫、杀菌和除草活性,结果表明,化合物的杀虫活性虽然较差,但所有化合物在药液质量浓度为1.0×10-4g/mL时都具有较好的除草活性,部分化合物在5.0×10-5g/mL时显示出良好的杀菌活性.

Nine novel title compounds were synthesized by the addition reactions of imines and cyclic phosphites, their structures were characterized by ^1H NMR, ^31p NMR, MS, elemental analysis and X-ray diffraction analysis. Preliminary bioassays indicate that all the compounds have good herbicidal activities and fungicidal activities to some extent.