摘要
In this paper the design and development of a novel experiment system and method for organic synthesis in a microfluidic were described chip.The phase-transfer reaction for the synthesis of 4-methoxy-benzaldehyde oxime from 4-methoxybenzaldehyde and hydroxylammonium chloride was carried out in glass microfluidic chips by using a negative pressure system to control the transformation reactants through the microchannels at a constant flow rate.The effect of reaction time on the yield was determined and compared with the standard batch system.The demonstrated advantages of organic synthesis in microfluidic chip included faster reaction rate,less consumption of reactants and labor contaminant,which proved microfluidic chip to be a powerful tool for synthetic applications.
In this paper the design and development of a novel experiment system and method for organic synthesis in a microfluidic were described chip. The phase-transfer reaction for the synthesis of 4-methoxy-benzaldehyde oxime from 4-methoxybenzaldehyde and hydroxylammonium chloride was carried out in glass microfluidic chips by using a negative pressure system to control the transformation reactants through the microchannels at a constant flow rate. The effect of reaction time on the yield was determined and compared with the standard batch system. The demonstrated advantages of organic synthesis in microfluidic chip included faster reaction rate, less consumption of reactants and labor contaminant, which proved microfluidic chip to be a powerful tool for synthetic applications.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2006年第11期2114-2116,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:20475049)资助
关键词
微流控芯片
相转移反应
对甲氧基苯甲醛肟
Microfluidic chip
Phase transfer reaction
4-Methoxybenzaldehyde oxime
