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Predicted epitopes of H5N1 bird flu virus by bioinformatics method: a clue for further vaccine development 被引量:1

Predicted epitopes of H5N1 bird flu virus by bioinformatics method: a clue for further vaccine development
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摘要 To the Editor: Bird flu or avian flu, caused by H5N1 virus, is a new emerging infectious disease. It is noted that this H5N1 virus jumped the species barrier and caused severe disease with high mortality in humans in many countries. The continued westward dissemination of H5N1 influenza A viruses in avian populations and the nearly 50% mortality of humans infected with H5N1 are a source of great international concern.1 Providing sufficient antiviral drugs and development and approval of new vaccines are the keys for control of the possible emerging pandemic of this atypical influenza.1'2 Based on the advance in bioinformatics, the immunomics becomes a new alternative in vaccine development.3 Advanced technologies for vaccine development, such as genome sequence analysis, microarray, proteomics approach, high-throughput cloning, bioinformatics database tools and computational vaccinology can be applied for vaccine development of several diseases including new emerging diseases. To the Editor: Bird flu or avian flu, caused by H5N1 virus, is a new emerging infectious disease. It is noted that this H5N1 virus jumped the species barrier and caused severe disease with high mortality in humans in many countries. The continued westward dissemination of H5N1 influenza A viruses in avian populations and the nearly 50% mortality of humans infected with H5N1 are a source of great international concern.1 Providing sufficient antiviral drugs and development and approval of new vaccines are the keys for control of the possible emerging pandemic of this atypical influenza.1'2 Based on the advance in bioinformatics, the immunomics becomes a new alternative in vaccine development.3 Advanced technologies for vaccine development, such as genome sequence analysis, microarray, proteomics approach, high-throughput cloning, bioinformatics database tools and computational vaccinology can be applied for vaccine development of several diseases including new emerging diseases.
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2006年第20期1760-1760,共1页 中华医学杂志(英文版)
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参考文献6

  • 1.H5N1 avian influenza: first steps towards development of a human vaccine[].Wkly Epidemiol Rec.2005
  • 2Guan P,Doytchinova IA,Zygouri C,Flower DR.MHCPred: bringing a quantitative dimension to the online prediction of MHC binding[].Applied Bioinformatics.2003
  • 3.From functional genomics to functional immunomics: new challenges, old problems, big rewards[].PLoS Comput Biol.2006
  • 4De Groot AS,Martin W.From immunome to vaccine: epitope mapping and vaccine design tools[].Novartis Foundation Symposium.2003
  • 5Boon AC,De Mutsert G,Fouchier RA,Sintnicolaas K,Osterhaus AD,Rimmelzwaan GF.Preferential HLA usage in the influenza virus-specific CTL response[].J Immunol.2004
  • 6Doherty PC,Turner SJ,Webby RG.Influenza and the challenge for immunology[].Nature Immunology.2006

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