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Effects of Bushen Zhuanggu Formul on interleukin-6 production and bone metabolism of the ovariectomized rats

Effects of Bushen Zhuanggu Formul on interleukin-6 production and bone metabolism of the ovariectomized rats
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摘要 Objective: To observe the effects of Bushen Zhuanggu Formul on intedeukin 6 (IL-6) level and bone metabolism of the ovariectomized rats, and to explore the possible mechanism of preventing and treating postmenopausal osteo porosis by traditional Chinese Formul. Methods: SD rats were randomly divided into 4 groups: normal control group (N), ovariectomized control group (OVX), estrogen-treated group (OVX+E) traditional and Chinese medicine-treated group (OVX+ CM). After treaanent, IL-6 levels in rat bone tissue media and serum were examined by ELISA. The proximal tibias(PTM) of rats were undecalcified for quantitative bone histomorphometry. Results: Compared with OVX group, both Bushen Zhuanggu medicine and estrogen decreased IL-6 level in rat bone tissue media. However, the effects of Bushen Zhuanggu Formul were weaker than those of estrogen. Furthermore, Bushen Zhuanggu Formul and estrogen produced a reduction in bone turnover by inhibiting bone formation and bone resorption at the same time. Conclusion: Bushen Zhuanggu Formul prevents ovariectomic bone loss by inhibiting IL-6 production in rat bone tissues. Objective: To observe the effects of Bushen Zhuanggu Formul on intedeukin 6 (IL-6) level and bone metabolism of the ovariectomized rats, and to explore the possible mechanism of preventing and treating postmenopausal osteo porosis by traditional Chinese Formul. Methods: SD rats were randomly divided into 4 groups: normal control group (N), ovariectomized control group (OVX), estrogen-treated group (OVX+E) traditional and Chinese medicine-treated group (OVX+ CM). After treaanent, IL-6 levels in rat bone tissue media and serum were examined by ELISA. The proximal tibias(PTM) of rats were undecalcified for quantitative bone histomorphometry. Results: Compared with OVX group, both Bushen Zhuanggu medicine and estrogen decreased IL-6 level in rat bone tissue media. However, the effects of Bushen Zhuanggu Formul were weaker than those of estrogen. Furthermore, Bushen Zhuanggu Formul and estrogen produced a reduction in bone turnover by inhibiting bone formation and bone resorption at the same time. Conclusion: Bushen Zhuanggu Formul prevents ovariectomic bone loss by inhibiting IL-6 production in rat bone tissues.
出处 《Journal of Nanjing Medical University》 2006年第4期193-196,共4页 南京医科大学学报(英文版)
基金 National Natural Science Foundation of China(39770930)
关键词 Bushen Zhuanggu Formul bone tissue INTERLEUKIN-6 bone histomorphometry Bushen Zhuanggu Formul bone tissue interleukin-6 bone histomorphometry
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参考文献2

  • 1Bente Klarlund Pedersen,Adam Steensberg,Pernille Keller,Charlotte Keller,Christian Fischer,Natalie Hiscock,Gerrit van Hall,Peter Plomgaard,Mark A. Febbraio.Muscle-derived interleukin-6: lipolytic, anti-inflammatory and immune regulatory effects[J].Pflügers Archiv - European Journal of Physiology.2003(1)
  • 2Chen Lulu,Zeng Tianshu,Xia Wenfang,Li Huiqin,Zhou Ming.The effect of estrogen on the Restoration of bone mass and bone quality in ovariectomized rats[J].Journal of Tongji Medical University.2000(4)

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