摘要急性缺血是导致室性心律失常、心脏性猝死的主要原因之一。本研究以经冠状动脉灌注的兔左心室楔形心肌组织块为对象，着重探讨了急性无灌注缺血过程中兔左心室内外膜心肌动作电位、跨壁复极离散度（transmural dispersion of repolarization，TDR）演变规律及室性心律失常发生机制。
7Rubulis A, Jensen J, Lundahl G, et al. Ischemia induces aggravalion of baseline rcpolarization abnormalities in left vent ricular hypert rophy: a delete rious interaction [ J ]. J Appl Physiol, 2006, 101(1):102-110.
8Yah GX, Joshi A, Guo D, et al. Phase 2 reentry as a trigger to initiate ventrieular fibrillation during early acute myocardial ischemia [J]. Circalation, 2004, 110(9):1036-1041.
9Furukawa T, Kimura S, Furukawa N, et hi. Role of cardiac ATP- regulated polassium channels in differenlial responses of endocardial and epiearial cells to ischemia[ J]. Circ Res, 1991, 68(6) :1693 - 1702.
10Kimura S, Bassett AL, Furukawa T, et al. Difference in the effect of metabolic inhibition on attion potenlial and calcium currents in endocardial and epicardial cells[ J ]. Circulation, 1991, 84 ( 2 ) :768 - 777.
