MARS人工肝在治疗重症胰腺炎中的应用

APPLICATION OF MOLECULAR ADSORBENT RECYCLING SYSTEM(MARS) IN TREATMENT TO SEVERE ACUTE PANCREATITIS

目的探讨MARS人工肝在治疗重症胰腺炎的疗效及其作用机制。方法对4例重症胰腺炎患者进行MARS治疗,对比治疗前后IL-1、IL-6、TNF-α、NO水平及血淀粉酶、脂肪酶、肝肾功能等的改变。结果4例患者,经MARS治疗后,临床症状及体征明显改善;血IL-1、IL-6、TNF-α、NO水平及淀粉酶、脂肪酶、肌酐、尿素氮、血总胆红素、谷丙转氨酶水平均明显降低(P<0.05)。结论MARS人工肝对治疗重症胰腺炎是一种有效辅助治疗手段。

Objective To study the effect and its mechanism of the molecular adsorbent recycling system（MARS） in the treatment of severe acute pancreatits. Methods 4 patients with severe acute-panceatitis were treated with MARS,the concentration cytokines IL-1, IL-6 ,TNF-α and NO in serum were compared before and after the treatment. Serum amlyase （AMS）, lipopolyase （LPS）, blood urea nitrogen （ BUN）, serum creatinie （ Scr ）, total bilirubin （ TB）, aspartate aminotransferase （ASE） were also observed. Results MARS therapy achieved a remarkable improvement in clinical symptoms and physic signs （ P 〈 0. 05 ）. Conclusions MARS is an effect assist treatment for patients with severe acute pancreatitis.